Abstract #1108
Repeatability of geometrically corrected DWI scans for treatment response monitoring in oesophageal cancer
Astrid L.H.M.W. van Lier 1 , Peter S.N. van Rossum 1,2 , Gert J. Meijer 1 , Cornelis A.T. van den Berg 1 , Marille E.P. Philippens 1 , Jan J.W. Lagendijk 1 , Marco van Vulpen 1 , and Irene M. Lips 1
1
Radiotherapy, UMC Utrecht, Utrecht, Utrecht,
Netherlands,
2
Surgery,
UMC Utrecht, Utrecht, Utrecht, Netherlands
Prior to constructing a model for DWI-based response
prediction in esophageal cancer, we investigated the
repeatability of the ADC determination in the tumor. As
the DWI images are geometrically distorted, we opted for
retrospective correction of the maps prior to analysis.
The coefficient of repeatability was found to be 11.0%
(Bland-Altman analysis). No significant correlation was
found between the ADC repeatability error and mean pixel
shift. The repeatability error was generally smaller
than the pre-per and pre-post treatment ADC difference
(8/11 cases). We will continue to use the proposed DWI
protocol for development of a treatment response
prediction model.
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