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Abstract #1120

Investigating MRI Biomarkers as Indicators of Early Treatment Response in a Triple Negative Model of Breast Cancer

Stephanie L. Barnes 1,2 , Jennifer G. Whisenant 1,2 , J. Oliver McIntyre 1,3 , and Thomas E. Yankeelov 1,2

1 Vanderbilt University Institute of Imaging Sciences, Vanderbilt University, Nashville, TN, United States, 2 Radiology and Radiological Sciences, Vanderbilt University, Nashville, TN, United States, 3 Cancer Biology, Vanderbilt University, Nashville, TN, United States

This work aims to assess the feasibility of diffusion weighted and dynamic contrast enhanced MRI (DW- and DCE-MRI, respectively) parameters as early (i.e., before tumor volume changes) indicators of treatment response to Abraxane in a preclinical model of triple negative breast cancer. We found that ADC and K trans were significantly different from the control group in both high and low dose treatment groups on day 2, prior to any observable difference in the tumor size. These results indicate that ADC from DW-MRI and K trans from DCE-MRI could serve as noninvasive, early indicators of treatment response.

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