Abstract #1120
Investigating MRI Biomarkers as Indicators of Early Treatment Response in a Triple Negative Model of Breast Cancer
Stephanie L. Barnes 1,2 , Jennifer G. Whisenant 1,2 , J. Oliver McIntyre 1,3 , and Thomas E. Yankeelov 1,2
1
Vanderbilt University Institute of Imaging
Sciences, Vanderbilt University, Nashville, TN, United
States,
2
Radiology
and Radiological Sciences, Vanderbilt University,
Nashville, TN, United States,
3
Cancer
Biology, Vanderbilt University, Nashville, TN, United
States
This work aims to assess the feasibility of diffusion
weighted and dynamic contrast enhanced MRI (DW- and DCE-MRI,
respectively) parameters as early (i.e., before tumor
volume changes) indicators of treatment response to
Abraxane in a preclinical model of triple negative
breast cancer. We found that ADC and
K
trans
were
significantly different from the control group in both
high and low dose treatment groups on day 2, prior to
any observable difference in the tumor size. These
results indicate that ADC from DW-MRI and
K
trans
from
DCE-MRI could serve as noninvasive, early indicators of
treatment response.
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