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Abstract #1121

Evaluation of tumor oxygenation in response to an indole-based vascular disrupting agent using 19 F MRI

Heling Zhou 1 , Rami R Hallac 2 , Rebecca Denney 1 , Li Li 1 , Ramona Lopez 1 , Li Liu 1 , Edward E Graves 3 , Mary Lynn Trawick 4 , Kevin G Pinney 4 , and Ralph P Mason 1

1 Radiology, University of Texas Southwestern Medical Center, Dallas, TX, United States, 2 Analytical Imaging and Modeling Center, Children's Medical Center, Dallas, TX, United States, 3 Radiation Oncology and Radiology, Stanford University, CA, United States, 4 Chemistry and Biochemistry, Baylor University, Waco, TX, United States

Oxi8007, a novel vascular disrupting agent, showed rapid and highly selective shutdown of tumor vasculature. In this study we explored the onset of hypoxia with FREDOM, a 19 F oxygen mapping technique, to assess the pO 2 changes following the administration of Oxi8007 at two different doses using an orthotopic breast cancer mouse model. Both dose groups showed rapid decrease of pO 2 though with a slower rate accompanying the lower dose. PO 2 maps revealed heterogeneous responses to the drug.

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