Abstract #1121
Evaluation of tumor oxygenation in response to an indole-based vascular disrupting agent using 19 F MRI
Heling Zhou 1 , Rami R Hallac 2 , Rebecca Denney 1 , Li Li 1 , Ramona Lopez 1 , Li Liu 1 , Edward E Graves 3 , Mary Lynn Trawick 4 , Kevin G Pinney 4 , and Ralph P Mason 1
1
Radiology, University of Texas Southwestern
Medical Center, Dallas, TX, United States,
2
Analytical
Imaging and Modeling Center, Children's Medical Center,
Dallas, TX, United States,
3
Radiation
Oncology and Radiology, Stanford University, CA, United
States,
4
Chemistry
and Biochemistry, Baylor University, Waco, TX, United
States
Oxi8007, a novel vascular disrupting agent, showed rapid
and highly selective shutdown of tumor vasculature. In
this study we explored the onset of hypoxia with FREDOM,
a
19
F
oxygen mapping technique, to assess the pO
2
changes
following the administration of Oxi8007 at two different
doses using an orthotopic breast cancer mouse model.
Both dose groups showed rapid decrease of pO
2
though
with a slower rate accompanying the lower dose. PO
2
maps
revealed heterogeneous responses to the drug.
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