Abstract #1127
Towards MRI-based measurement of tissue oxygen content
Scott C. Beeman 1 , John A. Engelbach 1 , Joseph J.H. Ackerman 1,2 , and Joel R. Garbow 1
1
Department of Radiology, Washington
University in Saint Louis, Saint Louis, Missouri, United
States,
2
Department
of Chemistry, Washington University in Saint Louis,
Saint Louis, Missouri, United States
We, and others, are pursuing a technique to measure
tissue oxygenation that takes advantage of the
paramagnetic property of molecular oxygen, as found
dissolved in tissue. Herein, we present a R
1
-based
breathing gas challenge technique that can distinguish
radiation damage from tumor - a distinction which has
been difficult to make using other methods. We further
show that the R
1
of
brain parenchyma can be measured by isolating the R
1
of
bulk water and suppressing flow contributions, and that
breathing of carbogen gas has a direct impact on the R
1
of
brain parenchyma.
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