Meeting Banner
Abstract #1128

Monitoring tumor response to the direct or indirect targeting of choline

Lionel Mignion 1 , Pierre Danhier 1 , Paolo E. Porporato 2 , Julie Magat 1 , Pierre Sonveaux 2 , Vincent Gregoire 3 , Bernard Gallez 1 , and Benedicte F. Jordan 1

1 Biomedical Magnetic Resonance Unit, Louvain Drug Research Institute, Universit Catholique de Louvain, Brussels, Belgium, 2 Pole of pharmacology, Institut de Recherche Exprimentale et Clinique, Universit Catholique de Louvain, Brussels, Belgium, 3 Pole of Molecular Imaging, Radiotherapy and Oncology, Universit Catholique de Louvain, Brussels, Belgium

The aim of the current study is to assess response to the modulation of the choline pathway, that is known to be involved in oncogenesis, by using specific choline kinase and transporters inhibitors and shRNA of choline kinase. In this work we proposed a combination of choline spectroscopy and diffusion markers to predict the tumor evolution after treatment. Using these combined markers we can assess the actual inhibition of the target in vivo and assess early tumor response non invasively, in order to avoid drug resistance with the ultimate goal of improving therapy individualization.

This abstract and the presentation materials are available to members only; a login is required.

Join Here