Abstract #1133
Gallium maltolate inhibits angiogenesis in brain tumor xenograft model
Kimberly R Pechman 1 , Andrew Lozen 1 , Christopher R Chitambar 2 , and Kathleen M Schmainda 3
1
Neurosurgery, Medical College of Wisconsin,
Milwaukee, WI, United States,
2
Medicine,
Medical College of Wisconsin, Milwaukee, WI, United
States,
3
Radiology
& Biophysics, Medical College of Wisconsin, Milwaukee,
WI, United States
Malignant brain tumors are difficult to treat and
patient survival is dismal. MRI measures of enhancing
tumor volume have proven unreliable since decreases in
enhancement may be independent of biologic effect. The
purpose of this study was to investigate a novel
therapy, gallium maltolate, for brain tumors using the
U87 xenograft model. In this study we used steady state
and DSC-MRI to measure tumor blood volume and flow. The
studies, demonstrate that the novel gallium maltolate
therapy inhibits brain tumor angiogenesis.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Click here for more information on becoming a member.
