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Abstract #1134

Feasibility of MR-guided needle-directed intratumoral HoMS delivery for localized radiation therapy in a large tumor-model

Bo Sybren van Leeuwen 1 , Sebastiaan Alexander van Nimwegen 2 , Frank Zijlstra 3 , Chris Oerlemans 3 , Jolle Kirpensteijn 2 , Johannes Franciscus Nijsen 4 , and Peter Roland Seevinck 3

1 Dept. of Clinical Sciences of Companion Animals, Faculty of Veterinary Medicine Utrecht University, Utrecht, Utrecht, Netherlands, 2 Dept. of Clinical Sciences of Companion Animals, Faculty of Veterinary Medicine Utrecht University, Utrecht, Netherlands, 3 Image Sciences Institute, Imaging Division, University Medical Center Utrecht, Utrecht, Utrecht, Netherlands, 4 Imaging Division, University Medical Center Utrecht, Utrecht, Netherlands

In this study, we demonstrated the feasibility of MR-guided needle-directed intratumoral 165HoMS delivery in a large tumor model. MRI facilitated tumor visualization, entry point determination and needle trajectory planning. The presented approach enabled dynamic monitoring of the needle insertion and needle tip positioning in the tumor, allowing intraprocedural optimization of HoMS delivery. coRASOR reconstruction was demonstrated to improve needle visualization by generating positive contrast, causing the titanium needles to be easily identified with high spatial and temporal resolution when applied prospectively. Future work should also aim at facilitating intraprocedural dosimetry to enable optimization of the number of injection sites and the amount of HoMS to be delivered to eventually provide a favorable dose distribution on the tumor, while sparing the healthy tissue.

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