Abstract #1141
Dynamic 3D Compressed Sensing MR of hyperpolarized 13C Pyruvate and Urea in Prostate Cancer Models
Hsin-Yu Chen 1 , Peder E. Z. Larson 2 , Cornelius von Morze 2 , Christine Leon Swisher 1 , Naeim Bahrami 2 , Robert Bok 2 , John Kurhanewicz 1,2 , and Daniel B. Vigneron 1,2
1
Graduate Program in Bioengineering, UCSF and
UC Berkeley, San Francisco, California, United States,
2
Department
of Radiology and Biomedical Imaging, University of
California, San Francisco, California, United States
Use of 3D compressed-sensing [13C]pyruvate and [13C]urea
MRSI sequence and dynamic models enables, for the first
time, simultaneous evaluation of metabolic and perfusion
parameters kpl and ktrans in a preclinical prostate
tumor model. We demonstrates increases in both pyruvate-to-lactate
conversion rate and perfusion/permeability in prostate
tumor versus normal tissue. This approach shows great
potential for the quantitative assessment of prostate
cancer aggressiveness and also treatment response.
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