Abstract #1141
Dynamic 3D Compressed Sensing MR of hyperpolarized 13C Pyruvate and Urea in Prostate Cancer Models
Hsin-Yu Chen 1 , Peder E. Z. Larson 2 , Cornelius von Morze 2 , Christine Leon Swisher 1 , Naeim Bahrami 2 , Robert Bok 2 , John Kurhanewicz 1,2 , and Daniel B. Vigneron 1,2
1
Graduate Program in Bioengineering, UCSF and
UC Berkeley, San Francisco, California, United States,
2
Department
of Radiology and Biomedical Imaging, University of
California, San Francisco, California, United States
Use of 3D compressed-sensing [13C]pyruvate and [13C]urea
MRSI sequence and dynamic models enables, for the first
time, simultaneous evaluation of metabolic and perfusion
parameters kpl and ktrans in a preclinical prostate
tumor model. We demonstrates increases in both pyruvate-to-lactate
conversion rate and perfusion/permeability in prostate
tumor versus normal tissue. This approach shows great
potential for the quantitative assessment of prostate
cancer aggressiveness and also treatment response.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Click here for more information on becoming a member.
