Simultaneous Hyperpolarized 13C Pyruvate and Urea Perfusion Parameterizations in Cancer
Naeim Bahrami 1 , Cornelius Von Morze 1 , Christine Leon 1 , Daniel B. Vigneron 1 , and Peder E.Z. Larson 1
Department of Radiology and Biomedical
Imaging, University of California, San Francisco,
California, United States
In cancerous tissue there is both existing vasculature
and neovascularization as different kinds of lesions
surpass the normal blood supply, including small
circulation disturbance in some of the abnormal vessels.
The variation of pyruvate perfusion and urea perfusion
can be observed for the healthy and cancerous tissues.
The urea perfusion is primarily representing the
vasculature delivery in each specific tissue and it
stays in the vessels, while the pyruvate perfusion,which
is the accumulation of all source and derived
metabolites related to the pyruvate including
pyruvate,lactate and alanine, can also be a marker for
vascular delivery but also includes tissue uptake.
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