Abstract #1144
Combined Magnetic Resonance Spectroscopy and Mass Spectrometry Imaging of Breast Tumor Hypoxia
Asif Rizwan 1 , Lu Jiang 1 , Nadine Mascini 2 , Vadappuram P Chacko 1 , Menglin Cheng 1 , Venu Raman 1,3 , Zaver M Bhujwalla 1,3 , Ron Heeren 2 , and Kristine Glunde 1,3
1
Radiology and Radiological Science, The
Johns Hopkins University School of Medicine, Baltimore,
Maryland, United States,
2
FOM
Institute AMOLF, Amsterdam, Netherlands,
3
The
Sidney Kimmel Comprehensive Cancer Center, The Johns
Hopkins University School of Medicine, Baltimore,
Maryland, United States
Our goal is to identify a probe for imaging hypoxia in
breast cancer models, which can be detected in vivo by
magnetic resonance spectroscopy (MRS) and ex vivo by
mass spectrometry imaging (MSI). We tested hypoxyprobe
F6, which was intravenously injected in breast tumor
xenograft bearing mice, and detected in vivo using 19F
MRS. Following sacrifice of mice and tumor removal, the
hypoxia probes F6 and pimonidazole were imaged for the
first time ex vivo by matrix-assisted laser desorption
ionization (MALDI) MSI. Hypoxyprobe F6 has the potential
to be a multimodality imaging reporter for hypoxia
detection by MRS and MSI.
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