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Abstract #1144

Combined Magnetic Resonance Spectroscopy and Mass Spectrometry Imaging of Breast Tumor Hypoxia

Asif Rizwan 1 , Lu Jiang 1 , Nadine Mascini 2 , Vadappuram P Chacko 1 , Menglin Cheng 1 , Venu Raman 1,3 , Zaver M Bhujwalla 1,3 , Ron Heeren 2 , and Kristine Glunde 1,3

1 Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States, 2 FOM Institute AMOLF, Amsterdam, Netherlands, 3 The Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States

Our goal is to identify a probe for imaging hypoxia in breast cancer models, which can be detected in vivo by magnetic resonance spectroscopy (MRS) and ex vivo by mass spectrometry imaging (MSI). We tested hypoxyprobe F6, which was intravenously injected in breast tumor xenograft bearing mice, and detected in vivo using 19F MRS. Following sacrifice of mice and tumor removal, the hypoxia probes F6 and pimonidazole were imaged for the first time ex vivo by matrix-assisted laser desorption ionization (MALDI) MSI. Hypoxyprobe F6 has the potential to be a multimodality imaging reporter for hypoxia detection by MRS and MSI.

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