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Abstract #1145

Neurochemical profile differentiation of glioma induced by cancer stem cells expressing WIF1: a 1 H-MRS longitudinal study at 14.1T

Marta Lai 1 , Cristina Cudalbu 2 , Bernard Lanz 1,3 , Irene Vassallo 4 , Marie-France Hamou 4 , Monika Hegi 4 , and Rolf Gruetter 2,5

1 Laboratory of Functional and Metabolic Imaging (LIFMET), Ecole Polytechnique Fdrale de Lausanne, Lausanne, Switzerland, 2 Centre dImagerie Biomedicale, Ecole Polytechnique Fdrale de Lausanne, Lausanne, Switzerland, 3 Department of Radiology, University of Lausanne, Lausanne, Switzerland, 4 Laboratory of Brain Tumor Biology and Genetics, Department of Neurosurgery, Lausanne University Hospital, Lausanne, Switzerland, 5 Departments of Radiology, University of Lausanne and Geneva, Switzerland

WIF1 gene has been recently identified as a tumor suppressor gene in glioblastoma. Human glioma stem cells have been genetically modified for the expression of the WIF1 gene, they were injected intracranially in NUDE mice for 1 H MRS analysis and compared with a group of mice injected with the analogue cell line without modifications. Quantification of 1 H MRS spectra acquired longitudinally throughout the tumor development showed distinct metabolic features in the two groups of mice which correlate with a less aggressive phenotype for glioma stem cells expressing WIF1.

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