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Abstract #1146

Localized, Non-invasive In Vivo Measurement of Enzymatic Activity using MAD-STEAM HP 13C MRSI

Christine Leon Swisher 1,2 , Peder E.Z. Larson 1,2 , Robert A. Bok 1 , Justin Delos Santos 1 , Romelyn Delos Santos 1 , Hsin-Yu Chen 1,2 , Adam B. Kerr 3 , John M. Pauly 3 , Sarah J. Nelson 1,2 , John Kurhanewicz 1,2 , and Daniel B. Vigneron 1,2

1 Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA, United States, 2 UC Berkeley-UCSF Graduate Program in Bioengineering, San Francisco, CA, United States, 3 Magnetic Resonance Systems Research Laboratory, Department of Electrical Engineering, Stanford University, Stanford, CA, United States

MAD-STEAM MRSI provides a simple and robust method for parametric mapping with increased specificity to cellular exchange without concomitant signals from arterial input or T1 relaxation. We show that this technique correlates with enzymatic activity (R2= 0.883) and can be used to non-invasively measure enzymatic activity in vivo and identify regions with high enzymatic activity (p-value = 0.003). In the field of oncology in particular, this new technique has great biomedical and clinical significance, as it could be used to better identify particularly aggressive regions within tumors, target image-guided biopsies, monitor cancer progression, and follow response to therapy.

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