Abstract #1146
Localized, Non-invasive In Vivo Measurement of Enzymatic Activity using MAD-STEAM HP 13C MRSI
Christine Leon Swisher 1,2 , Peder E.Z. Larson 1,2 , Robert A. Bok 1 , Justin Delos Santos 1 , Romelyn Delos Santos 1 , Hsin-Yu Chen 1,2 , Adam B. Kerr 3 , John M. Pauly 3 , Sarah J. Nelson 1,2 , John Kurhanewicz 1,2 , and Daniel B. Vigneron 1,2
1
Department of Radiology and Biomedical
Imaging, University of California, San Francisco, San
Francisco, CA, United States,
2
UC
Berkeley-UCSF Graduate Program in Bioengineering, San
Francisco, CA, United States,
3
Magnetic
Resonance Systems Research Laboratory, Department of
Electrical Engineering, Stanford University, Stanford,
CA, United States
MAD-STEAM MRSI provides a simple and robust method for
parametric mapping with increased specificity to
cellular exchange without concomitant signals from
arterial input or T1 relaxation. We show that this
technique correlates with enzymatic activity (R2= 0.883)
and can be used to non-invasively measure enzymatic
activity in vivo and identify regions with high
enzymatic activity (p-value = 0.003). In the field of
oncology in particular, this new technique has great
biomedical and clinical significance, as it could be
used to better identify particularly aggressive regions
within tumors, target image-guided biopsies, monitor
cancer progression, and follow response to therapy.
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