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Abstract #1147

Effect of c-Myc Expression on Cellular-Interstitial Water Exchange Kinetics: Conditional Transgenic Mouse Breast Cancer Model

Ramesh Paudyal 1 , Sergey Magnitsky 2 , Steve Pickup 3 , Lewis A. Chodosh 4 , Charles Springer 5 , and Jerry D. Glickson 3

1 Yerkes Imaging Center, Yerkes Regional Primate Research Center, Emory University, Atlanta, GA, United States, 2 Radiology, USCF, CA, United States, 3 Radiology, University of Pennsylvania, Philadelphia, PA, United States, 4 Department of Cancer Biology, University of Pennsylvania, Philadelphia, PA, United States, 5 Advanced Imaging Research Center, Oregon Health & Science University, OR, United States

In this study, we evaluate the effect on cellular-interstitial water exchange in Transgenic MTB/TOM mice DCE-MRI data, which conditionally express the human oncogene c-myc in mammary glands in response to doxycycline (dox) treatment, using Shutter Speed Model (SSM). The data were measured with dox and 4 days after withdrawal of dox. Herein, we observed a significant decrease in Ktrans and ti after a removal of dox. Changes in Ktrans and ti might serve as surrogate biomarkers in breast cancer study.

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