Abstract #1148
Correlation between in vivo and ex vivo MRI of mouse mammary glands with regards to apparent diffusion coefficient and T2 values
Xiaobing Fan 1 , Kay Macleod 2 , Devkumar Mustafi 1 , Suzanne D Conzen 3 , Erica Markiewicz 1 , Marta Zamora 1 , Jim Vosicky 1 , Jeffrey Mueller 4 , and Gregory S Karczmar 1
1
Department of Radiology, The University of
Chicago, Chicago, IL, United States,
2
Ben
May Department for Cancer Research, The University of
Chicago, Chicago, IL, United States,
3
Medicine,
Hematology/Oncology, The University of Chicago, Chicago,
Chicago, IL, United States,
4
Department
of Pathology, The University of Chicago, Chicago, IL,
United States
High resolution ex vivo imaging can improve
understanding of cancer and guide evaluation of surgical
specimens. The rationale for ex vivo MRI is strengthened
if there is a strong correlation between ex vivo and in
vivo images. Here we evaluate MRI at 9.4 Tesla of a
mouse model (n = 7) of breast cancer. For ex vivo
experiments, excised skin and glands were wrapped around
a sponge to maintain the in vivo spatial configuration.
There was a strong correlation (0.73 < r < 0.86, p <
0.0001) between the in vivo and ex vivo ADCs and T2s.
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