Abstract #1149
Dual biomarker CEST-MRI evaluates tumor pH and vascular perfusion in an orthotopic ovarian cancer model
Liu Qi Chen 1 , Kyle Mitchell Jones 2 , Christine Howison 3 , Setsuko K Chambers 4 , Amanda Baker 5 , and Mark Pagel 6
1
Chemistry, University of Arizona, Tucson,
Arizona, United States,
2
Biomedical
Engineering, University of Arizona, Tucson, AZ, United
States,
3
Biomedical
Engineering, University of Arizona, Tucson, Arizona,
United States,
4
Obstetrics
and gynecology, University of Arizona, Arizona, United
States,
5
Pharmacology,
University of Arizona, Tucson, Arizona, United States,
6
Biomedical
Engineering and Chemistry, University of Arizona,
Tucson, Arizona, United States
Extracellular pH (pHe) is a hallmark for tumor
microenvironment. AcidoCEST MRI is a noninvasive MRI
method that can measure pHe to assess tumor acidosis.
This method allows for a pixel by pixel pH analysis that
can accurately determine spatial heterogeneity of the
tumor as well as contrast agent uptake. In this study,
acidoCEST MRI was used to assess an SKOV3 ovarian tumor
model. Our results showed that the tumor model was
mildly acidic, with an average pH of 6.88. Additionally,
tumor acidosis and lower perfusion were correlated with
larger ovarian tumors.
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