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Abstract #1149

Dual biomarker CEST-MRI evaluates tumor pH and vascular perfusion in an orthotopic ovarian cancer model

Liu Qi Chen 1 , Kyle Mitchell Jones 2 , Christine Howison 3 , Setsuko K Chambers 4 , Amanda Baker 5 , and Mark Pagel 6

1 Chemistry, University of Arizona, Tucson, Arizona, United States, 2 Biomedical Engineering, University of Arizona, Tucson, AZ, United States, 3 Biomedical Engineering, University of Arizona, Tucson, Arizona, United States, 4 Obstetrics and gynecology, University of Arizona, Arizona, United States, 5 Pharmacology, University of Arizona, Tucson, Arizona, United States, 6 Biomedical Engineering and Chemistry, University of Arizona, Tucson, Arizona, United States

Extracellular pH (pHe) is a hallmark for tumor microenvironment. AcidoCEST MRI is a noninvasive MRI method that can measure pHe to assess tumor acidosis. This method allows for a pixel by pixel pH analysis that can accurately determine spatial heterogeneity of the tumor as well as contrast agent uptake. In this study, acidoCEST MRI was used to assess an SKOV3 ovarian tumor model. Our results showed that the tumor model was mildly acidic, with an average pH of 6.88. Additionally, tumor acidosis and lower perfusion were correlated with larger ovarian tumors.

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