Feasibility of amide proton transfer imaging of rodent glioblastoma model at 3T clinical scanner

In this work, a practical amide proton transfer (APT) imaging method for small animal brain at 3T clinical scanner was developed using a multi-shot sequence with k-space trajectory of 2D interleaved variable-density (VD) spiral-out. This method was applied on 4 orthotropic GBM xenograft models in immune-deficient rats. This study demonstrated elevated APT effect within the tumors with measured APT ratio ranging from 3.40 to 5.28% (4.20.83; meanS.D.) consistent with prior studies. Efficient use of gradient hardware in VD spiral sequence allowed small field-of-view acquisition while maintaining reasonable signal-to-noise ratio for small animal brain scan at clinical 3T scanner.

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