Abstract #1150
Feasibility of amide proton transfer imaging of rodent glioblastoma model at 3T clinical scanner
Jinsuh Kim 1 and Phillip Zhe Sun 2
1
Radiology, University of Iowa, Iowa City,
IA, United States,
2
Radiology,
A. A. Martinos Center for Biomedical Imaging,
Massachusetts General Hospital, Boston, MA, United
States
In this work, a practical amide proton transfer (APT)
imaging method for small animal brain at 3T clinical
scanner was developed using a multi-shot sequence with
k-space trajectory of 2D interleaved variable-density
(VD) spiral-out. This method was applied on 4
orthotropic GBM xenograft models in immune-deficient
rats. This study demonstrated elevated APT effect within
the tumors with measured APT ratio ranging from 3.40 to
5.28% (4.20.83; meanS.D.) consistent with prior
studies. Efficient use of gradient hardware in VD spiral
sequence allowed small field-of-view acquisition while
maintaining reasonable signal-to-noise ratio for small
animal brain scan at clinical 3T scanner.
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