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Abstract #1154

In-Vitro Detection of Apoptosis Using Oscillating and Pulsed Gradient Diffusion Magnetic Resonance Imaging

Sharon Portnoy 1 , Nicole D. Fichtner 2 , Claudia Dziegielewski 1 , Martin P. Stanisz 1 , and Greg J. Stanisz 1,2

1 Sunnybrook Research Institute, Toronto, Ontario, Canada, 2 Department of Medical Biophysics, University of Toronto, Ontario, Canada

A wide range of diffusion experiments and a simple model of diffusion in tissues were used to probe the microstructural effects of apoptosis. Experiments were conducted on acute myeloid leukemia (AML) cell pellets, where apoptosis was induced by treatment with the chemotherapeutic agent, cisplatin. Seventy-two hours following treatment pulsed (PGSE) and oscillating (OGSE) gradient diffusion measurements were performed to assess effects across a broad range of structural scales. The presence of apoptosis,which was confirmed by histology, significantly altered diffusion properties.

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