Abstract #1154
In-Vitro Detection of Apoptosis Using Oscillating and Pulsed Gradient Diffusion Magnetic Resonance Imaging
Sharon Portnoy 1 , Nicole D. Fichtner 2 , Claudia Dziegielewski 1 , Martin P. Stanisz 1 , and Greg J. Stanisz 1,2
1
Sunnybrook Research Institute, Toronto,
Ontario, Canada,
2
Department
of Medical Biophysics, University of Toronto, Ontario,
Canada
A wide range of diffusion experiments and a simple model
of diffusion in tissues were used to probe the
microstructural effects of apoptosis. Experiments were
conducted on acute myeloid leukemia (AML) cell pellets,
where apoptosis was induced by treatment with the
chemotherapeutic agent, cisplatin. Seventy-two hours
following treatment pulsed (PGSE) and oscillating (OGSE)
gradient diffusion measurements were performed to assess
effects across a broad range of structural scales. The
presence of apoptosis,which was confirmed by histology,
significantly altered diffusion properties.
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