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Abstract #1153

1 Tesla Bench-top MRI of a Mouse Model of Colorectal Carcinoma Metastasis in the Liver: Comparison with 9.4 Tesla

Rajiv Ramasawmy* 1,2 , Thomas Roberts* 1,3 , Bernard Siow 1 , Sean Peter Johnson 1,2 , Jack Anthony Wells 1 , Alan Bainbridge 4 , Rosamund Barbara Pedley 2 , Mark Francis Lythgoe 1 , and Simon Walker-Samuel 1

1 Centre for Advanced Biomedical Imaging, University College London, London, Greater London, United Kingdom, 2 Cancer Institute, University College London, London, Greater London, United Kingdom, 3 Centre for Mathematics and Physics in the Life Sciences and Experimental Biology, University College London, London, Greater London, United Kingdom, 4 Department of Medical Physics, University College London, London, Greater London, United Kingdom

Low-field pre-clinical MRI scanners offer economical imaging of small animal models of cancer, although whether they provide sufficient signal-to-noise for the detection of tumours within reasonable imaging times is currently unknown. In this study, tumour and liver volumes were measured in a mouse model of liver metastasis using a 1T bench-top MRI system and a 9.4T scanner. Volumetric comparison was performed, alongside signal-to-noise characterisation and contrast assessment between tumour and liver. T1 and T2 mapping is also reported. Volumetric analysis of livers and tumours showed good correspondence, suggesting that bench-top MRI scanners potentially offer a cost-effective platform for accurately monitoring deep-seated tumour models and liver diseases.

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