On conductivity, permittivity, apparent diffusion coefficients and their use as cancer markers at MRI frequencies
Ileana Hancu 1 , Jeanette Roberts 1 , Seung-Kyun Lee 1 , Robert Lenkinski 2 , and Selaka Bulumulla 1
GE Global Research Center, Niskayuna, NY,
Southwestern Medical Center, TX, United States
Experiments using an impedance analyzer/dielectric probe
were performed in two rat cancer models to validate the
frequency dependant differences in tissue electrical
properties (TEP's) between cancer and normal tissues.
Correlations between conductivity and apparent diffusion
coefficient (ADC) were also investigated. While it was
found that limited differences (5-30%) exist between the
TEP's of cancer and normal tissue, permittivity added
significant discriminant power compared to ADC alone,
particularly at 1.5T and 3T. If MRI based TEP
measurements could be brought to ~5%
accuracy/repeatability, it is suggested that 3T exams
involving ADC and permittivity mapping could better
discern cancer from normal tissue.
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