Abstract #1163
PEG-masked ferritin-based multifunctional nanoparticles in melanoma murine model
Giulia Carpinelli 1 , Rossella Canese 1 , Elisabetta Falvo 2 , Cristina Maria Failla 3 , Miriam Carbo 2 , Manuela Fornara 4 , Serena Cecchetti 1 , Lenka Rajsiglova 5 , Dmitry Stakheev 5 , Jiri Krizan 5 , Alberto Boffi 2,4 , Veronica Morea 2 , Luca Vannucci 5 , and Pierpaolo Ceci 2
1
Cell Biology and Neurosciences Dept,
Istituto Superiore di Sanit, Rome, Italy,
2
Institute
of Molecular Biology and Pathology, CNR National
Research Council of Italy, Rome, Italy,
3
Molecular
and Cell Biology Laboratory, IDI-IRCCS, Rome, Italy,
4
Department
of Biochemical Sciences A. Rossi Fanelli, University
of Rome Sapienza, Rome, Italy,
5
Institute
of Microbiology, Academy of Sciences of the Czech
Republic (ASCR), Prague, Czech Republic
Nanoparticles (NPs) are promising agents for enhancing
cancer diagnosis and treatment. Once functionalized for
selective targeting of tumor expressed molecules, they
can specifically deliver drugs and diagnostic molecules
inside tumor cells. We evaluated the in vivo
melanoma-targeting ability of a nanovector (HFt-MSH-PEG)
based on human protein ferritin (HFt), functionalized
with both melanoma-targeting melanoma stimulating
hormone (α-MSH) and stabilizing poly(ethylene glycol)
molecules, with magnetite-maghemite encapsulation. NPs
showed by MRI an accumulation in primary melanoma, with
high selectivity with respect to other organs, thereby
proving to be suitable vectors for selective delivery of
diagnostic or therapeutic agents for cutaneous melanoma.
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