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Abstract #1163

PEG-masked ferritin-based multifunctional nanoparticles in melanoma murine model

Giulia Carpinelli 1 , Rossella Canese 1 , Elisabetta Falvo 2 , Cristina Maria Failla 3 , Miriam Carbo 2 , Manuela Fornara 4 , Serena Cecchetti 1 , Lenka Rajsiglova 5 , Dmitry Stakheev 5 , Jiri Krizan 5 , Alberto Boffi 2,4 , Veronica Morea 2 , Luca Vannucci 5 , and Pierpaolo Ceci 2

1 Cell Biology and Neurosciences Dept, Istituto Superiore di Sanit, Rome, Italy, 2 Institute of Molecular Biology and Pathology, CNR National Research Council of Italy, Rome, Italy, 3 Molecular and Cell Biology Laboratory, IDI-IRCCS, Rome, Italy, 4 Department of Biochemical Sciences A. Rossi Fanelli, University of Rome Sapienza, Rome, Italy, 5 Institute of Microbiology, Academy of Sciences of the Czech Republic (ASCR), Prague, Czech Republic

Nanoparticles (NPs) are promising agents for enhancing cancer diagnosis and treatment. Once functionalized for selective targeting of tumor expressed molecules, they can specifically deliver drugs and diagnostic molecules inside tumor cells. We evaluated the in vivo melanoma-targeting ability of a nanovector (HFt-MSH-PEG) based on human protein ferritin (HFt), functionalized with both melanoma-targeting melanoma stimulating hormone (α-MSH) and stabilizing poly(ethylene glycol) molecules, with magnetite-maghemite encapsulation. NPs showed by MRI an accumulation in primary melanoma, with high selectivity with respect to other organs, thereby proving to be suitable vectors for selective delivery of diagnostic or therapeutic agents for cutaneous melanoma.

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