Abstract #1169
Investigation of Relationship between Free-Water T1 and Age in Human Cortical Bone Employing Short-TE 1H-MRI at 1.5T
Atena Akbari 1,2 , Shahrokh Abbasi Rad 1,2 , Mohsen Shojaee Moghaddam 3 , and Hamidreza Saligheh Rad 1,2
1
Medical Physics and Biomedical Engineering
Department, Tehran University of Medical Sciences,
Tehran, Tehran, Iran,
2
Quantitative
MR Imaging and Spectroscopy Group, Research Center for
Molecular and Cellular Imaging, Tehran, Tehran, Iran,
3
Imaging
Center, Payambaran Hospital, Tehran, Tehran, Iran
Larger pores in human cortical bone (>30 m) have
essential role in its mechanical competence, suggesting
to quantify such proton pools as a reliable measure of
cortical bone porosity and thus, cortical bone quality.
Signal from such pores can be reliably captured using
short echo time (STE) pulse sequence with echo-time in
range of 0.5-1msec. Furthermore, it is well-known that
cortical bone T1-relaxivity is a function of its
geometrical characteristics, suggesting
subject-dependent cortical bone free water increasing
with age. In this work, we investigated relationship
between STE-based cortical bone T1-values and age,
studies in a group of healthy volunteers at 1.5T.
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