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Abstract #1175

Quantification of Scar Tissue Formed Around Cranial Bone Grafts, and Its Reduction by Parathyroid Hormone Therapy

Doron Cohn Yakubovich 1 , Uzi Eliav 2 , Michal Rivlin 2 , Ilan Kallai 1 , Gadi Pelled 1,3 , Dan Gazit 1,3 , Zulma Gazit 1,3 , and Gil Navon 2

1 Skeletal Biotech Laboratory, The Hebrew University of Jerusalem, Jerusalem, Israel, 2 School of Chemistry, Tel Aviv University, Tel Aviv, Israel, 3 Department of Surgery, Regenerative Medicine Institute, Cedars-Sinai Medical Center, Los Angeles, California, United States

In order to examine parathyroid hormone (PTH, a bone anabolic agent) effect on scar tissue formation at calvarial bone grafts proximity, we used MRI scanning protocol, consisted of MTC and double quantum filtering to measure collagen fiber deposition in the scar-bone suture. We hypothesize that this quantitative MRI technique for evaluating collagen deposition will confirm that PTH administration decreases collagenous scar tissue formation. Indeed, in- and ex-vivo MRI revealed changes in collagen as in comparison to the control animals, enabling differentiation between new bone formation and scar tissue. Our technique will enable physicians longitudinal, non-invasive follow up of various fibrosis related conditions.

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