Abstract #1175
Quantification of Scar Tissue Formed Around Cranial Bone Grafts, and Its Reduction by Parathyroid Hormone Therapy
Doron Cohn Yakubovich 1 , Uzi Eliav 2 , Michal Rivlin 2 , Ilan Kallai 1 , Gadi Pelled 1,3 , Dan Gazit 1,3 , Zulma Gazit 1,3 , and Gil Navon 2
1
Skeletal Biotech Laboratory, The Hebrew
University of Jerusalem, Jerusalem, Israel,
2
School
of Chemistry, Tel Aviv University, Tel Aviv, Israel,
3
Department
of Surgery, Regenerative Medicine Institute,
Cedars-Sinai Medical Center, Los Angeles, California,
United States
In order to examine parathyroid hormone (PTH, a bone
anabolic agent) effect on scar tissue formation at
calvarial bone grafts proximity, we used MRI scanning
protocol, consisted of MTC and double quantum filtering
to measure collagen fiber deposition in the scar-bone
suture. We hypothesize that this quantitative MRI
technique for evaluating collagen deposition will
confirm that PTH administration decreases collagenous
scar tissue formation. Indeed, in- and ex-vivo MRI
revealed changes in collagen as in comparison to the
control animals, enabling differentiation between new
bone formation and scar tissue. Our technique will
enable physicians longitudinal, non-invasive follow up
of various fibrosis related conditions.
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