Abstract #1203
Diffusion of manganese oxide nanoparticles into articular cartilage
Susanna Ahola 1 , Ville-Veikko Telkki 1 , Eveliina Lammentausta 2 , Jessica M. Rosenholm 3 , Elli-Noora Salo 2 , Gamzegul M. Behrouz 1 , Roberto Blanco Sequeiros 2,4 , and Miika T. Nieminen 2,4
1
Department of Physics, University of Oulu,
Oulu, Oulu, Finland,
2
Department
of Diagnostic Radiology, Oulu University Hospital, Oulu,
Finland,
3
Centre
of Functional Materials, Laboratory of Physical
Chemistry, bo Akademi University, Turku, Finland,
4
Department
of Radiology, University of Oulu, Oulu, Finland
Feasibility of new manganese oxide nanoparticles (MnOx)
as contrast agent for articular cartilage was
investigated in vitro. The diffusion of MnOx into
articular cartilage was followed by measuring T1 maps
for 24 hours at repeated intervals after immersing
osteochondral samples into the MnOx and, subsequently,
after immersing the sample in saline solution for
another 24 hours. For comparison, the post-contrast part
of the study was repeated with Gd-DTPA solution. MnOx
diffused rapidly into cartilage and appears to
permanently bind in high concentration to a region near
the calcified zone. Thus MnOx is a potential biomarker
for highlighting the cartilage-bone interface.
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