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Abstract #1203

Diffusion of manganese oxide nanoparticles into articular cartilage

Susanna Ahola 1 , Ville-Veikko Telkki 1 , Eveliina Lammentausta 2 , Jessica M. Rosenholm 3 , Elli-Noora Salo 2 , Gamzegul M. Behrouz 1 , Roberto Blanco Sequeiros 2,4 , and Miika T. Nieminen 2,4

1 Department of Physics, University of Oulu, Oulu, Oulu, Finland, 2 Department of Diagnostic Radiology, Oulu University Hospital, Oulu, Finland, 3 Centre of Functional Materials, Laboratory of Physical Chemistry, bo Akademi University, Turku, Finland, 4 Department of Radiology, University of Oulu, Oulu, Finland

Feasibility of new manganese oxide nanoparticles (MnOx) as contrast agent for articular cartilage was investigated in vitro. The diffusion of MnOx into articular cartilage was followed by measuring T1 maps for 24 hours at repeated intervals after immersing osteochondral samples into the MnOx and, subsequently, after immersing the sample in saline solution for another 24 hours. For comparison, the post-contrast part of the study was repeated with Gd-DTPA solution. MnOx diffused rapidly into cartilage and appears to permanently bind in high concentration to a region near the calcified zone. Thus MnOx is a potential biomarker for highlighting the cartilage-bone interface.

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