Abstract #1204
Incorporation of Rician Noise in the Analysis of Biexponential Transverse Relaxation in Cartilage using a Multiple Gradient Echo Sequence at 3T and 7T
Mustapha Bouhrara 1 , David A Reiter 1 , Hasan Celik 1 , Jean-Marie Bonny 2 , Vanessa Lukas 1 , Kenneth W Fishbein 1 , and Richard G Spencer 1
1
NIA, NIH, Baltimore, Maryland, United
States,
2
QuaPa,
INRA, Saint Gens Champanelle, France
The noise distribution of magnitude MR data obtained
through quadrature detection exhibits a Rician, rather
than Gaussian, probability distribution. Previous work
has assessed the importance of thisin fitting
monoexponential decay curves. Recently, there has been a
renewed interest in tissue compartmentation studies
through use of multiexponential analysis. Accordingly,
we extend the analysis of the effect of Rician noise to
the much more complex problem of biexponential decay
through use of Monte Carlo simulations, and phantom and
cartilage explant studies. We find that explicit
incorporation of the Rician statistical characteristics
of the signal leads to markedly improved results.
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