Abstract #1211
Multiparametric therapy study of the goat cartilage after inducing Osteoarthritis
Joachim Hermann Xaver Schrauth 1,2 , Gunthard Lykowsky 1,2 , Daniel Weber 1 , Jakob Kreutner 1,2 , Kathrin Hemberger 1,2 , Lars Rackwitz 3 , Ulrich Nth 3 , Peter Jakob 1,2 , and Daniel Haddad 1
1
Molecular & Cellular MRI, MRB Research
Center for Magnetic Resonance Bavaria, Wuerzburg,
Bavaria, Germany,
2
Experimental
Physics 5 (Biophysics), University Wuerzburg, Wuerzburg,
Bavaria, Germany,
3
Knig-Ludwig-Haus,
Orthopdische Universittsklinik Wrzburg, Wuerzburg,
Bavaria, Germany
The aim of this study was to compare Sodium, T1ρ and
dGEMRIC measurements for the characterization of the
goat cartilage after inducing Osteoarthritis in a
control and cell based treated group. The results of all
methods show expected behavior over the course of 16
weeks after the defect, though T1ρ seems to be most
sensitive to early changes in the cartilage. Moreover we
found a very strong correlation between the both known
dGEMRIC indices and moderate correlations between Sodium
& dGEMRIC(1), dGEMRIC(1) & T1ρ and dGEMRIC(2) & T1ρ.
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