Abstract #1212
Magnetic Resonance Imaging of Viscosupplementations: A Preliminary Report
Mohammad Haris 1,2 , Anup Singh 1 , Kejia Cai 1,3 , J. Bruce Kneeland 4 , Fotios Tjoumakaris 5 , Hari Hariharan 1 , and Ravinder Reddy 1
1
CMROI, Radiology, University of
Pennsylvania, Philadelphia, Pennsylvania, United States,
2
Research
Branch, Sidra Medical and Research Center, Doha, Qatar,
3
CMRR
3T Research Program, University of Illinois at Chicago,
Chicago, IL, United States,
4
Radiology,
University of Pennsylvania, Philadelphia, Pennsylvania,
United States,
5
Sports
Medicine at Rothman institute, Thomas Jefferson
University Hospital, Philadelphia, Pennsylvania, United
States
The concept of viscosupplementation has gained
widespread acceptance as a new treatment for the
management of osteoarthritis (OA) of the knee. Here, we
evaluate the chemical-exchange-saturation-transfer
effect from the two popular viscosupplementations (Synvisc
and Orthovisc) by exploiting the exchangeable hydroxyl
groups present on these molecules at 7T human scanner.
Both viscosupplementations showed a strong CEST effect
at ~1 ppm. Furthermore, using the CEST technique it may
possible to map the fate of the injected
viscosupplementation in knee joints of OA patients over
time as well as their effect on knee cartilage GAG
concentration.
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