Tensor based morphometry to evaluate longitudinal changes in the femoral cartilage of subjects with osteoarthritis: Data from the Osteoarthritis Initiative (OAI).

Osteoarthritis causes among other changes, loss in cartilage volume which increases as the disease progresses. Cartilage loss with disease progression is small and localized to sub regions of the cartilage, making detection challenging. We report the deformation (Jacobian) maps of femoral cartilage in a longitudinal study (baseline and 12 mo.) to identify subtle and localized interval changes. Subject data from the Osteoarthritis Initiative which had segmented cartilage in longitudinal studies was used. The Jacobian maps allow visualization of small and localized changes and could potentially enable population based studies on cartilage morphometry.

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