The Origin that Darkens the Deep Region of Articular Cartilage in MRI when Loaded at the Magic Angle

To investigate the molecular origin that darkens the deep-region of articular cartilage when the tissue is compressed and oriented at the magic angle, T2 and T1ρ experiments were used to study native and degraded cartilage. The glycosaminoglycan (GAG) concentrations in the specimens were quantified by both sodium ICP-OES and T1-Gd methods. The GAG concentration was found to play the key role in the formation of this low-intensity layer in the deep-region of the compressed cartilage. A schematic model has been formulated to explain the structural differences in the deformation of the collagen matrix between native and degraded tissues.

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