Abstract #1231
Using 31 P-MRS to Explore the Effects of Iron Deficiency on Murine Skeletal Muscle Function and Metabolism During Exercise
M. Kate Curtis 1 , Lowri E. Cochlin 2 , Mark A. Cole 3 , David P. O'Neill 1 , Michael S. Dodd 1,4 , Damian J. Tyler 1,4 , Kieran Clarke 1 , and Peter A. Robbins 1
1
Department of Physiology, Anatomy and
Genetics, University of Oxford, Oxford, United Kingdom,
2
Department
of Physiology, Anatomy and Genetics, PulseTeq Ltd,
Oxford, United Kingdom,
3
Department
of Life Sciences, University of Nottingham Medical
School, Nottingham, United Kingdom,
4
Oxford
Centre for Clinical Magnetic Resonance Research,
Radcliffe Department of Medicine, University of Oxford,
Oxford, United Kingdom
Physical work or exercise capacity has been widely
reported as being impaired by iron deficiency in both
human and animal studies. The aim of this project was to
develop a technique that allows for the simultaneous
assessment of force production, fatigue resistance and
metabolic function of murine gastrocnemius muscle during
exercise. To address this, a method of in vivo
gastrocnemius muscle stimulation was successfully
established, which allows the simultaneous measurement
of energetics, by 31P MRS, and induced force production
in a murine model of altered iron status.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Click here for more information on becoming a member.
