Abstract #1232
Measurement of Trabecular Bone Quality In Vivo using Decay due to Diffusion in the Internal Field (DDIF) MRI
Sara Maria Sprinkhuizen 1 , Miriam Bredella 2 , Martin Torriani 2 , Anne Klibanski 3 , Pouneh K. Fazeli 3 , Scott Daley 2 , Ela Jane Cross 3 , Jerome Ackerman 1 , and Yi-Qiao Song 1,4
1
MGH/HST Athinoula A. Martinos Center for
Biomedical Imaging, Charlestown, MA, United States,
2
MGH
Musculoskeletal Imaging, MA, United States,
3
MGH
Neuroendocrine Unit, MA, United States,
4
Schlumberger-Doll
Research, Cambridge, MA, United States
Bone quality is currently measured with dual energy
x-ray absorptiometry (DXA), which assesses the bone
mineral density (BMD). However, BMD is just one of
several factors contributing to bone quality. The
microstructural geometry of bone is another, very
important, factor in determining bone strength and can
be measured using Decay due to Diffusion in the Internal
Field (DDIF) MRI. The current work was aimed at
understanding the relation between DDIF MRI and clinical
BMD values. The DDIF technique was applied in the lumbar
spine of healthy controls and patients with anorexia
nervosa and compared to BMD values obtained using DXA.
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