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Abstract #1232

Measurement of Trabecular Bone Quality In Vivo using Decay due to Diffusion in the Internal Field (DDIF) MRI

Sara Maria Sprinkhuizen 1 , Miriam Bredella 2 , Martin Torriani 2 , Anne Klibanski 3 , Pouneh K. Fazeli 3 , Scott Daley 2 , Ela Jane Cross 3 , Jerome Ackerman 1 , and Yi-Qiao Song 1,4

1 MGH/HST Athinoula A. Martinos Center for Biomedical Imaging, Charlestown, MA, United States, 2 MGH Musculoskeletal Imaging, MA, United States, 3 MGH Neuroendocrine Unit, MA, United States, 4 Schlumberger-Doll Research, Cambridge, MA, United States

Bone quality is currently measured with dual energy x-ray absorptiometry (DXA), which assesses the bone mineral density (BMD). However, BMD is just one of several factors contributing to bone quality. The microstructural geometry of bone is another, very important, factor in determining bone strength and can be measured using Decay due to Diffusion in the Internal Field (DDIF) MRI. The current work was aimed at understanding the relation between DDIF MRI and clinical BMD values. The DDIF technique was applied in the lumbar spine of healthy controls and patients with anorexia nervosa and compared to BMD values obtained using DXA.

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