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Abstract #1246

Intravoxel Incoherent Motion (IVIM) MR Imaging of Degenerated Intervertebral Lumbar disks: an initial experience

Niu Gang 1 , Liu Zhe 1 , Du Yong Hao 1 , and Yang Jian 1,2

1 Department of Radiology, the first affiliated hospital of medical college, Xian Jiaotong University, Xi'an, Shaanxi, China, 2 Department of Biomedical Engineering, School of Life Science and Technology, Xi' an Jiaotong University, Xi'an, Shaanxi, China

The aim of this study is to assess the feasibility of using intravoxel incoherent motion(IVIM) MRI in vivo to detect intervertebral disk degeneration(IVDD). 23 patients (14 men and 9 women; mean age 40 years; median age 47; age range 21~73 years) with low back pain or sciatica underwent IVIM MRI and T2 weighted images (T2WIs). It was showed that the pure diffusion ADClow of disk decrease with increased the Pfirrmann grades based on T2WI in this study, which indicated the decreased real diffusivity of free waterin IVDD. We also observed increased pseudodiffusion coefficient ADCfast values of AF with increased Pfirrmann grades,.The results demonstrated not only the significant differences in ADCfast of NP between grade I and IV, grade II and IV (ANOVA, P0.05), but also the significant differences in ADCfast of AF between grade I and IV, II and IV, III and IV (ANOVA, P0.05), which suggested an increasing microcapillary perfusionin IVDD. In sum, IVIM MR imaging may provide an objective and non-invasive biomarker for estimating diffusivity and microcapillary perfusion in IVDD.

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