Abstract #1245
Detection of Extracellular Matrix Degradation in Intervertebral Disc Degeneration by Diffusion Magnetic Resonance Spectroscopy (DW-MRS)
Anna M. WANG 1,2 , Adrian Tsang 1,2 , Peng Cao 1,2 , Danny Chan 3 , and Ed X. Wu 1,2
1
Laboratory of Biomedical Imaging and Signal
Processing, The University of Hong Kong, Hong Kong, Hong
Kong,
2
Department
of Electrical and Electronic Engineering, The University
of Hong Kong, Hong Kong, Hong Kong,
3
Department
of Biochemistry, The University of Hong Kong, Hong Kong
This study explored the capability of Diffusion Weighted
Magnetic Resonance Spectroscopy (DW-MRS) to detect and
characterize the ECM degradation during the early stage
of IVDD. The apparent diffusion coefficient (ADC) of
macromolecule resonances increased by approximately ten
fold immediately after papain injection, and continued
to increase in the following 5 days. The macromolecule
T2 also had a slight increase during the ECM degradation
and the macromolecule content is corrected by their
corresponding T2 value. The macromolecule content, water
T2 and ADC value showed a delayed change compared to the
macromolecule ADCs. The macromolecule ADC is an early
marker of the microstructural breakdown of PGs and
collagen network in the disc NP during IVDD and hence
DW-MRS is sensitive to detect disc degeneration at an
early stage.
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