Abstract #1401
Combining MRI with PET for partial volume correction improves image-derived input functions in mice
Eleanor Evans 1 , David Izquierdo Garcia 2 , Guido Buonincontri 1 , Carmen Methner 3 , Rob C Hawkes 1 , Thomas Kreig 3 , T. Adrian Carpenter 1 , and Stephen J Sawiak 1,4
1
Wolfson Brain Imaging Centre, University of
Cambridge, Cambridge, United Kingdom,
2
Athinoula
A. Martinos Centre for Biomedical Imaging, Harvard
University, Massachusetts, United States,
3
Department
of Medicine, University of Cambridge, Cambridge, United
Kingdom,
4
Behavioural
and Clinical Neurosciences Institute, University of
Cambridge, Cambridge, United Kingdom
Kinetic modelling in Positron Emission Tomography (PET)
allows metabolic measures to be obtained, but requires
the tracer arterial input function (AIF). Blood sampling
to acquire the AIF is prohibitive in mice due to low
blood volumes. Image-derived AIFs are therefore
preferred, although their extraction from blood vessels
is hampered by low spatial resolution (~1.5-2mm). We
found that using an AIF extraction method which employed
partial volume correction (PVC) in the mouse heart was
crucial for deriving accurate AIFs and gave best results
when ROIs were based on MRI data rather than PET data.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Click here for more information on becoming a member.
