Two-voxel Hadamard encoded semi-LASER spectroscopy for in vivo MRS at ultra-high field

Large chemical shift displacement errors in MRS at ultra-high field can limit SNR and lead to spurious J-evolution across the VOI. Multi-voxel approaches are particularly susceptible to poor localisation, resulting in signal bleed between voxels. By incorporating two-voxel Hadamard encoding with a semi-LASER localisation sequence at 7T, we show that both CSD and inter-voxel bleeding can be minimised. Demonstrating this method in vivo on 4 volunteers, we are able to obtain highly resolved spectra with efficient water suppression simultaneously from both voxels. Metabolites such as GABA, Glu, Lac and Ins can be reliably determined with the method.

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