Abstract #1418
Effect of embedding media on post-mortem MRI of formalin-fixed brain tissue at 7.0 T
Petr Dusek 1,2 , Vince Istvan Madai 3 , Matthias Dieringer 4,5 , Fabian Hezel 4 , Thoralf Niendorf 4,5 , Jan Sobesky 3,5 , Radoslav Matej 6 , and Jens Wuerfel 1,7
1
Institute of Neuroradiology, University
Medicine Goettingen, Goettingen, Germany,
2
Department
of Neurology and Center of Clinical Neuroscience,
Charles University in Prague, 1st Faculty of Medicine
and General University Hospital in Prague, Praha, Czech
Republic,
3
Department
of Neurology and Center for Stroke Research Berlin
(CSB), Charit-Universitaetsmedizin, Berlin, Germany,
4
Berlin
Ultrahigh Field Facility (B.U.F.F.), Max-Delbrueck
Center for Molecular Medicine, Berlin, Germany,
5
Experimental
and Clinical Research Center (ECRC),
Charit-Universitaetsmedizin and Max Delbrueck Center
for Molecular Medicine (MDC), Berlin, Germany,
6
Department
of Pathology and Molecular Medicine, Thomayer Teaching
Hospital, Praha, Czech Republic,
7
NeuroCure
Clinical Research Center, Charit-Universitaetsmedizin,
Berlin, Germany
It is well known that formalin fixation of post-mortem
material affects its contrast mechanism and MR
characteristics. It is however not clear how these
parameters and image quality are affected by the medium
in which is the post-mortem material embedded during
scanning. Our goal was to compare different embedding
media (deuterium oxide (D2O), formalin, low-melting
temperature agarose and phosphate-buffered-saline) for
post-mortem MRI and ascertain which gives the best
signal-to-noise ratio and contrast results. Also, we
wanted to find out whether embedding medium has
influence on signal intensity of formalin fixed brain
slices. We employed T2 mapping, T1 mapping, T2* mapping,
MP-RAGE and TIRM sequences. The results for all
embedding media are shown.
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