Partial Volume Correction for 23 Na MRI of Human Brain

The tissue sodium ( ²³ Na) concentration is of great interest in biomedical research. However the ²³ Na nucleus has a low MR sensitivity and fast relaxation times which requires larger voxel sizes in ²³ Na MRI. Thus, partial volume effects reduce the accuracy of concentration measurements. In this work, a partial volume correction method was transferred to ²³ Na MRI, optimized and tested in phantom measurements and simulations as wells as in ²³ Na MRI of the human brain. The study showed good correction capability for phantom and in-vivo data.

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