Abstract #1672
Signal Model Consistency Analysis of Different Protocols and Spectral Models in Multi Gradient Echo Liver PDFF and R 2 * Quantification
Mario A. Bacher 1,2 , Xiaodong Zhong 3 , Brian M. Dale 4 , Marcel D. Nickel 2 , Berthold Kiefer 2 , Mustafa R. Bashir 5 , Rudolf Stollberger 1 , and Stephan A.R. Kannengiesser 2
1
Institute of Medical Engineering, Technical
University Graz, Graz, Austria,
2
MR
Applications Development, Siemens AG, Healthcare Sector,
Erlangen, Germany,
3
MR
R&D Collaborations, Siemens Healthcare, Atlanta, GA,
United States,
4
MR
R&D Collaborations, Siemens Healthcare, Cary, NC, United
States,
5
Department
of Radiology, Duke University Medical Center, Durham,
NC, United States
Multi gradient echo quantification of liver proton
density fat fraction (PDFF) and transverse relaxation
rate (R2*) was analyzed using model consistency metrics.
Different acquisition protocols and fat spectral models
as reconstruction parameters were compared. Data from
twenty healthy volunteers showed no significant
differences in PDFF for different protocols, but
significant differences in PDFF and R2* for different
protocols and spectral models. With respect to fitting
error, the protocols were significantly different,
whereas the spectral models were not significantly
different from each other. Model consistency analysis is
a useful tool for evaluating multi gradient echo imaging
with advanced quantification
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