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Abstract #1671

On the Effect of Fat Suppression via Chemically Selective Saturation (CHESS) Pulses on R 2 * Measurements in Patients with Transfusional Iron Overload

Axel Joachim Krafft 1 , Ralf B. Loeffler 1 , Xiao Bian 1,2 , Ruitian Song 1 , Beth M. McCarville 1 , Jane S. Hankins 3 , and Claudia M. Hillenbrand 1

1 Radiological Sciences, St. Jude Children's Research Hospital, Memphis, TN, United States, 2 Rhodes College, Memphis, TN, United States, 3 Hematology, St. Jude Children's Research Hospital, Memphis, TN, United States

Fat is a confounder in R2* based liver iron assessment as fat-water modulations in multi gradient echo imaging eventually affect the T2* evaluation. A simple solution could be the inclusion of fat suppression (FS) via chemically selective saturation (CHESS). However, decreasing T2* times as observed with increasing liver iron correspond to spectral profiles which overlap with the CHESS frequency band. This partial saturation potentially alters R2* leading to a biased iron evaluation. Here, the effect of CHESS FS on R2* is measured in 65 transfusional iron overload patients. A phenomenological model is presented to explain and correct the observed changes.

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