MRI Acquisition and Analysis Protocol for In Vivo Grey Matter and White Matter Cross-Sectional Area Measurements in the Lumbo-Sacral Enlargement at 3T

A new image acquisition and analysis protocol is presented allowing segmentation of grey matter (GM) and white matter (WM) within the lumbo-sacral enlargement (LSE) at 3T. The optimised image acquisition scheme in conjunction with a robust image analysis method represents a clinically-viable method for obtaining reproducible measurements of GM and WM cross-sectional areas (CSA) within the LSE. In this work, normative tissue-specific CSA data are presented, hitherto unreported; future studies will investigate the value of the method presented here for assessing neurological diseases.

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