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Abstract #1727

Multisite DTI of the spinal cord with integrated template and white matter atlas processing pipeline

Julien Cohen-Adad 1,2 , Rebecca S Samson 3 , Torben Schneider 3 , Alex K Smith 4 , Marc Benhamou 1 , Geoffrey Leveque 1 , Seth A Smith 5 , and Claudia A M Wheeler-Kingshott 3

1 Institute of Biomedical Engineering, Polytechnique Montreal, Montreal, QC, Canada, 2 Functional Neuroimaging Unit, IUGM, Universite de Montreal, Montreal, QC, Canada, 3 NMR Research Unit, Queen Square MS Centre, Department of Neuroinflammation, UCL Institute of Neurology, United Kingdom, 4 Vanderbilt University Institute of Imaging Science (VUIIS), Department of Radiology and Radiological Sciences, Vanderbilt University, Tennessee, United States, 5 Department of Biomedical Engineering, Vanderbilt University, Tennessee, United States

We propose a framework for conducting DTI studies of the spinal cord across sites equipped with different MRI systems. The main features are: well-validated acquisition protocol including reduced field of view technique, registration to an existing spinal cord template using state-of-the-art methods and the use of a white matter atlas for quantifying DTI metrics in specific spinal tracts. The method is applicable to other acquisition techniques, such as magnetization transfer and functional MRI.

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