Abstract #1730
Correcting Myelin Water Fraction for T2 Changes Caused by Varying Phosphate Buffer Concentration in Aldehyde Fixed Spinal Cord Tissue
Henry Szu-Meng Chen 1,2 , Nathan Holmes 3 , Wolfram Tetzlaff 3,4 , and Piotr Kozlowski 3,5
1
UBC MRI Research Centre, Vancouver, British
Columbia, Canada,
2
Physics
and Astronomy, University of British Columbia,
Vancouver, BC, Canada,
3
ICORD,
Vancouver, BC, Canada,
4
Zoology,
University of British Columbia, Vancouver, BC, Canada,
5
Radiology,
University of British Columbia, Vancouver, BC, Canada
This study looked at the impact of phosphate buffer (PB)
concentration on MR measurements of myelin water
fraction (MWF) in
ex
vivo
rat
spinal cord. The results show that T2 shortens as the
concentration of PB decreases, which lead to a decrease
in T2 of both the intra/extracellular and myelin water
peak that inflate the measured MWF. The effect can
corrected for by moving the upper bound of myelin water
T2 range to the mean T2 of the two peaks as long as the
myelin water T2 is long enough to be well characterized
by the given echo time.
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