Abstract #1732
Phase Sensitive Inversion Recovery in Post Mortem Multiple Sclerosis Spinal Cord: Shades of Grey and White
Amy McDowell 1 , Marc Miquel 2 , Maria Papachatzaki 1 , Daniele Carassiti 1 , and Klaus Schmierer 1
1
Neuroscience and Trauma, Blizard Institute,
London, Greater London, United Kingdom,
2
Clinical
Physics, Barts Health NHS Trust, London, Greater, United
Kingdom
The usefulness of phase sensitive inversion recovery (PSIR)
images in fixed post mortem multiple sclerosis (MS)
spinal cord white matter (WM) and grey matter (GM) is
examined. PSIR was optimised using T1 values acquired at
3T (inversion recovery method). The values obtained, and
particularly the minor difference of T1 in WM and GM,
suggest the assessment of the histological substrate of
PSIR in post mortem spinal cord may not be feasible
using fixed tissue. The use of unfixed samples should be
explored, though access is limited
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