Resting-state functional MRI for evaluation of brain development from childhood to young adulthood
Mengxing Wang 1 , Jing Zhang 1 , Guohua Shen 1 , Jilei Zhang 1 , Kaihua Zhang 1 , Guang Yang 1 , and Xiaoxia Du* 1
Shanghai Key Laboratory of Magnetic
Resonance, Department of Physics, East China Normal
University, Shanghai, Shanghai, China
We investigated the developmental aspects of local
intrinsic activity, functional connectivity (FC) from
childhood to young adulthood using resting-state
functional MRI. There were three groups participated in
this study: 20 children, 20 adolescents and 23 young
adults. The amplitude of low-frequency fluctuation (ALFF)
significant changes were mainly in frontal lobe, limbic
lobe and cerebellum posterior lobe among three groups.
The FC difference were in frontal lobe (superior,
inferior and medial frontal gyri), cerebellum posterior
lobe, parietal lobe (inferior parietal lobule and
postcentral gyrus), as well in insula, caudate and
anterior cingulate among three groups.
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