Development of cortical hubs in childhood and adolescence: a graph theoretical analysis in fMRI

Whole-brain graph theoretical analysis was used in resting state fMRI data to identify brain regions that become stronger network hubs with age. 104 healthy subjects between the ages of 7 and 22 years were scanned and their EC maps were correlated with age. Non-parametric testing revealed that the posterior cingulate and ventromedial prefrontal cortices become significantly stronger hubs with age, while the frontal lobes and subcortical structures become significantly weaker hubs during a critical period of development. EC-based developmental analyses are a novel approach to evaluating network development and may provide further insight into areas of vulnerability for developmental delay.

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