Abstract #1746
LAPLACE BELTRAMI BASED QUANTIFICATION OF CORTICAL GYRIFICATION IN THE FETAL BRAIN
Rosita Shishegar 1,2 , Joanne M. Britto 3 , and Leigh A. Johnston 1,3
1
Electrical and Electronic Engineering,
University of Melbourne, Melbourne, VIC, Australia,
2
NICTA
Victoria Research Laboratory, Melbourne, VIC, Australia,
3
Florey
Institute of Neuroscience and Mental Health, Melbourne,
VIC, Australia
A quantitative assessment of cortical gyrification
through-out development is necessary for complete
understanding of normal brain development and
neuro-developmental disorders. MRI has been widely used
in the computation of gyrification indices (GIs). The
slice direction, however, is known to influence GI. We
present a modified GI computed using the Laplace
Beltrami (LB) operator, which uses the intrinsic
geometry of the cortex, rather than being constrained by
slice orientation. Cortical folding is quantified using
eigenvalues of the LB operator. We demonstrate that
LB-based metrics are useful measures of cortical
gyrification and complexity across key developmental
time-points in the fetal sheep brain.
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