Abstract #1745
In vivo assement of neurite density in the preterm brain using diffusion magnetic resonance imaging
Serena J Counsell 1,2 , Hui Zhang 3 , Emer Hughes 1,2 , Heather Steele 1 , Nora Tusor 1,2 , Gareth Ball 1,2 , Antonios Makropoulos 1,2 , Daniel C Alexander 3 , Joseph V Hajnal 1,2 , and A David Edwards 1,2
1
Centre for the Developing Brain, King's
College London, London, London, United Kingdom,
2
Division
of Imaging Sciences & Biomedical Engineering, King's
College London, London, London, United Kingdom,
3
Dept
of Computer Science & Centre for Medical Image
Computing, University College London, London, United
Kingdom
Preterm birth results in dysmaturation of cerebral grey
and white matter (WM). Our aims were to assess neurite
density index (NDI) in WM and thalamus in the preterm
brain at term equivalent age. We studied 44 preterm
infants, median (range) GA at birth 30 (24+232+5) and
post-menstrual age (PMA) at scan 42+1 (38+347+1) weeks.
Diffusion MRI was acquired in 2 shells; b value 750
s/mm2 , 32 directions and b value 2500 s/mm2, 64
directions at 3T. Our initial results suggest that
neurite density index is more sensitive than fractional
anisotropy to WM microstructural changes associated with
maturation.
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