Abstract #1753
White Matter Microstructure in Moderate and Late Preterm Infants assessed using Tract-Based Spatial Statistics
Deanne K Thompson 1,2 , Claire E Kelly 1 , Alexander Leemans 3 , Lillian Gabra Fam 1,4 , Marc L Seal 1,4 , Lex W Doyle 1,5 , Peter J Anderson 1,4 , Alicia J Spittle 1,5 , and Jeanie LY Cheong 1,5
1
Murdoch Childrens Research Institute,
Melbourne, VIC, Australia,
2
Florey
Institute of Neuroscience and Mental Health, Melbourne,
VIC, Australia,
3
Image
Sciences Institute, University Medical Center Utrecht,
Utrecht, Netherlands,
4
Department
of Paediatrics, University of Melbourne, Melbourne, VIC,
Australia,
5
Royal
Women's Hospital, Melbourne, VIC, Australia
Few studies have investigated the effects of moderate or
late preterm birth (MLPT, 32+0-36+6 weeks gestation) on
brain development using MRI. This study compared whole
brain white matter microstructure between 185 MLPT
infants and 70 term-born controls (born ≥37 weeks
gestation) at term-equivalent age using Tract-Based
Spatial Statistics analysis of diffusion tensor data.
There were widespread regions of lower fractional
anisotropy and higher axial, radial and mean
diffusivities in MLPT infants than controls, suggesting
that white matter microstructure is altered in MLPT
infants compared with controls. MLPT infants may be at
higher risk of altered white matter development than
previously recognised.
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