Abstract #1754
Microstructural development of the corpus callosum catches up between term and 7 years in children born <30 weeks gestation or <1250 g
Deanne K Thompson 1,2 , Loeka Van Bijnen 1 , Katherine J Lee 1,3 , Alexander Leemans 4 , Leona Pascoe 1 , Shannon E Scratch 1 , Christopher Adamson 1 , Gary F Egan 5,6 , Lex W Doyle 7 , Terrie E Inder 8 , and Peter J Anderson 1,3
1
Murdoch Childrens Research Institute,
Melbourne, Victoria, Australia,
2
Florey
Institute of Neuroscience and Mental Health, Melbourne,
Victoria, Australia,
3
Paediatrics,
University of Melbourne, Melbourne, Victoria, Australia,
4
Imaging
Science Institute, Utrecht, Netherlands,
5
Biomedical
Imaging, Monash University, Melbourne, Victoria,
Australia,
6
florey
Institute of Neuroscience and Mental Health, Melbourne,
Victoria, Australia,
7
Royal
Women's Hospital, Melbourne, Victoria, Australia,
8
Brigham
and Women's Hospital, Boston, Massachusettes, United
States
It is unknown whether early alterations to the corpus
callosum (CC) persist or resolve over time. We aimed to
determine whether longitudinal CC development occurs
faster or slower in preterm children compared with term
controls; and whether longitudinal CC development is
associated with neurodevelopmental functioning.
Diffusion tractography was performed at term-equivalent
and 7 years in 76 very preterm and 16 controls. Preterm
CC tract volume increased and diffusivity decreased more
over time than controls. Greater reduction in
diffusivity measures over time was associated with
better cognitive and motor functioning. Thus corpus
callosum development catches up after early insult.
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