Abstract #1755
Apparent Fibre Density Abnormalities in Adolescents Born Extremely Preterm: Moving Beyond the Diffusion Tensor
David Raffelt 1 , Jeanie LY Cheong 2,3 , Farnoosh Sadeghian 1 , Deanne K Thompson 3,4 , Peter J Anderson 3,5 , Lex W Doyle 2,3 , and Alan Connelly 1,6
1
Florey Institute of Neuroscience and Mental
Health, Melbourne, VIC, Australia,
2
Neonatal
Services, Royal Womens Hospital, Melbourne, VIC,
Australia,
3
Victorian
Infant Brain Studies, Murdoch Childrens Research
Institute, Melbourne, VIC, Australia,
4
Developmental
Imaging, Murdoch Childrens Research Institute,
Melbourne, VIC, Australia,
5
Department of
Paediatrics, University of Melbourne, Melbourne, VIC,
Australia,
6
Department
of Medicine, University of Melbourne, Melbourne, VIC,
Australia
Preterm birth is associated with increased risk of
health and developmental problems in childhood and
adolescence. White matter abnormalities have been
reported previously in preterm born adolescents using
the diffusion tensor, however these results are
difficult to interpret in regions with crossing fibres.
In this study we investigate preterm born adolescence
using Apparent Fibre Density (AFD), a quantitative
measure that is tract specific, even in voxels with
multiple fibres. When compared to term-born controls, we
observed a decrease in AFD in numerous white matter
tracts. We also observed significant AFD correlations
with a range of perinatal factors.
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