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Abstract #1755

Apparent Fibre Density Abnormalities in Adolescents Born Extremely Preterm: Moving Beyond the Diffusion Tensor

David Raffelt 1 , Jeanie LY Cheong 2,3 , Farnoosh Sadeghian 1 , Deanne K Thompson 3,4 , Peter J Anderson 3,5 , Lex W Doyle 2,3 , and Alan Connelly 1,6

1 Florey Institute of Neuroscience and Mental Health, Melbourne, VIC, Australia, 2 Neonatal Services, Royal Womens Hospital, Melbourne, VIC, Australia, 3 Victorian Infant Brain Studies, Murdoch Childrens Research Institute, Melbourne, VIC, Australia, 4 Developmental Imaging, Murdoch Childrens Research Institute, Melbourne, VIC, Australia, 5 Department of Paediatrics, University of Melbourne, Melbourne, VIC, Australia, 6 Department of Medicine, University of Melbourne, Melbourne, VIC, Australia

Preterm birth is associated with increased risk of health and developmental problems in childhood and adolescence. White matter abnormalities have been reported previously in preterm born adolescents using the diffusion tensor, however these results are difficult to interpret in regions with crossing fibres. In this study we investigate preterm born adolescence using Apparent Fibre Density (AFD), a quantitative measure that is tract specific, even in voxels with multiple fibres. When compared to term-born controls, we observed a decrease in AFD in numerous white matter tracts. We also observed significant AFD correlations with a range of perinatal factors.

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