Altered structural brain networks in children with Asperger syndrome: a DTI-based connectome study
Haoxiang Jiang 1,2 , Yanni Chen 2 , Qinli Sun 1,3 , Xianjun Li 3 , Mengye Lv 3 , Yang Song 1 , and Jian Yang 1,3
Department of Diagnostic Radiology, The
First Hospital of Medical School,Xi'an Jiaotong
University, Xi'an, Shannxi, China,
of Diagnostic Radiology, Xi'an Children Hospital, Xi'an,
of Biomedical Engineering, School of Life Science and
Technology, Xi'an Jiaotong University, Xi'an, Shannxi,
The aim of this study is to investigate the altered
structural brain networks based on diffusion tensor
imaging (DTI ) in children with Asperger syndrome(AS).
22 boys with AS and 18 typically developing(TD) children
with matched age and sex were collected. The results of
this study indicated the topological alterations of
white matter network in AS group compared to the TD
group. Meanwhile, network-based statistic result
displayed disrupted connected components in the right
hemisphere in AS group, especially those long-range
connections within the posterior part of the brain
cortex and thalamus and limbic system. DTI-based brain
network analysis can provide more objective estimation
of brain abnormal connectivity.
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